Effects of intravenous transplantation of MSCs on carcinogenesis in rats

MSCs transplantation is a perspective method for many diseases treatment. However, the effect of MSCs on the carcinogenesis have not been sufficiently studied due to the different methods of the administration of therapeutic cell products and their different origin (autologous or allogeneic). The presence of cancer is an exclusion criterion for the patients in clinical trials, but it is known that cancer diagnostic methods are imperfect, especially at the early stages of carcinogenesis. In addition, the effect of MSCs on cancer depends on its type and tissue, and, of course, on the state of differentiation of the cells and their genetic profile. A large number of studies dedicated to the effects of MSCs on cancer were performed on immunodeficient animals with local administration of allo- or xenogeneic MSCs at high doses. Therefore, the purpose of our research is to examine the impact of administration of autologous or allogeneic MSCs at different stages of cancerogenesis on the progression of tumors. Methods of cells administration were selected based on the existing clinical experience. Furthermore, we investigated the effect of allogeneic and xenogeneic transplantation of placenta-derived MSCs on rats at the middle stage of DMH-induced colon carcinogenesis. Allogeneic transplantation leads to an increase in tumor size at the fourth degree of invasion and reduces survival of rats bearing colon cancer by 17 days

 

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The average area of tumors at the 4th stage of invasion into intestinal wall increased in PDMCs group as compared to PS and Base groups.

 

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The number and size of tissue lesions after PDMC transplantation did not change significantly.

At the same time, placenta-derived MSCs can engraft in different organs including colon tumors. In terms of this study, we also isolated placenta-derived MSCs from both human and rat placentas, establishing primary mesenchymal stem cell culture, and described their basic characteristics in regard to the mesenchymal and trophoblast features. 

Referenced work  https://www.ncbi.nlm.nih.gov/pubmed/29552139

 

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