PSСL Team

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Volodymyr Shablii, PhD

Head of PlacentaStemCell Laboratory

I obtained PhD in Biotechnology at the department of Human Genetics, Institute of Molecular Biology and Genetics NAS of Ukraine in 2014. My research was focused on the study of mesenchymal stem cells isolated from placenta at different stages of human development (first-trimester and full term placenta), special attention was paid to the study of immunophenotype of cells, gene expression and multipotency of high proliferative subpopulation of placenta-derived multipotent cells (PDMCs). Furthermore, my research interests include the development of protocols for cryopreservation of placenta tissue as a source of various populations of stem cells. As a group leader I supervise different research projects that were performed in PlacentaStemCell Lab (PSC Lab). As a deputy director of Cryobank I am involved in the development of clinical-grade protocols of processing (isolation, expansion, and cryopreservation) of different cell based products. Nowadays, I launch the project dedicated to study the role of expression of endogenous retrovirus env ERVW-1/Syncytin-1 gene in extraembryonic mesoderm cells. For in vivo functional study of ENVs we are working on the establishing chicken embryo model

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Viktoriia Nikulina, PhD

Researcher, PlacentaStemCell Laboratory

I completed my PhD at the Taras Shevchenko National University of Kyiv in the Cell biology program (2015). My research interests include development of methods of placental tissue cryopreservation with high mesenchymal stem cells recovery, the influence of freezing on stem cells molecular and cellular properties. Also, I am involved in current study of new stem therapy products, organization pre-clinical and clinical assessment of therapeutic efficacy for the treatment of autoimmune diseases and regeneration of cartilaginous tissue. I was awarded the grant of the President of Ukraine to support research of young scientists in 2017

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Maria Kuchma, PhD

Researcher, PlacentaStemCell Laboratory

I have been working in PlacentaStemCell Lab since it was founded in 2010. The main directions of my work are the methods of isolation, preservation, expansion and study the features of human Hematopoietic Stem Cells from human placental tissue. The results of these works in PSC Lab became basic to get a PhD in Institute of Molecular Biology and Genetics of NAS of Ukraine at 2015. Also, I am a co-author of the manufacturing method of isolation, expansion and cryopreservation of placenta-derived multipotent cells in PlacentaStemCell Lab. I was involved in the group that developed an effective product of cell therapy for regeneration of cartilaginous tissue (clinical assessment)

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Tetiana Bukreieva

Researcher, PlacentaStemCell Laboratory

I completed my Masters at the Department of Biosynthesis of Nucleic Acids, Institute of Molecular Biology and Genetics NAS of Ukraine. Then I pursued my research career as a scientific researcher in the PSC Lab, Institute of Cell Therapy. I took part in studies regarding the dimethylhydrazine-induced colon carcinogenesis after PDMCs transplantation in rats. My current project is dedicated to the elaboration of the technology of cellular cardiomyoplasty with the use of stem cells. Also, I have an experience in the organization of pre-clinical and clinical assessment for cell therapy

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Oleksandr Zhuk

Researcher, PlacentaStemCell Laboratory

I obtained Master’s degree in histology at the Taras Shevchenko National University of Kyiv in 2018. I am currently a biologist at the PlacentaStemCell Lab, Institute of Cell Therapy. My laboratory studies include endogenous retrovirus env genes in genome of Gallus gallus and their expression during early embryogenesis. My research focuses on the study of structure of chicken env genes, temporal and spatial expression pattern, their role in embryo development and impact on evolution. I also focus on the study of the expression of env genes in extraembryonic mesenchyme, including MSCs subpopulation

Research partners / Collaborators

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Vitalii Kyryk, PhD, MD

Head of Cell and Tissue Culture Laboratory, State Institute of Genetic and Regenerative Medicine NAMS of Ukraine

Learn more: igrm.kiev.ua

Vitalii Kyryk graduated MD in Bukovinian State Medical University (2004) and he holds a PhD degree in the field of immunology at the Institute of Gerontology (2010). Vitalii has a broad background in stem cell technology, with specific training and expertise in cell isolation, multiparameter immunophenotyping and sorting by flow cytometry. As a group leader in the State Institute of Genetic and Regenerative Medicine Dr. Kyryk has an experience in developing basic research and clinical trials strategy, partners search, budget calculation, planning experiments, complex data processing and analysis. The research areas of Dr. Kyryk's group include the study of regenerative potential of stem cells of different origin (bone marrow-derived multipotent mesenchymal stromal cells, adipose-derived stem cells, placental stem cells, cardiac stem cells, neural stem cells, etc.) for the treatment of cardiovascular and central nervous system diseases, including ischemic cardiomyopathy, stroke and perinatal ischemic brain injuries

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Inessa Skrypkina, PhD, Senior Researcher

Head of Laboratory of Biosynthesis of Nucleic Acids, Department of Functional Genomics, Institute of Molecular Biology and Genetics of NASU

Learn more: imbg.org.ua/en/dept/funcgenomics/lab_biosynthesis/

I obtained a Ph.D. degree in Molecular Biology at the Institute of Molecular Biology and Genetics NAS of Ukraine in 2003. From 2018 I am the Head of the Laboratory of Biosynthesis of Nucleic Acids, IMBG NASU, Kyiv, Ukraine. My research interests are comprehensive and include the investigation of the mechanisms involved in malignant tumors initiation and progression in order to create the general therapeutic approaches to cancer treatment; the study of the proliferative and invasive properties of brain tumor cells and the search for specific inhibitors of these pathway signals; determination of genetic and epigenetic changes in extracellular nucleic acids of biological fluids in patients with cancer as diagnostic and prognostic markers of early non-invasive diagnosis; the role of microexons in the differentiation and development of stem neuronal cells. Together with the researchers from the PSC Lab, I take part in several projects, namely, to study the effect of MSC transplantation on carcinogenesis in rats, the role of ENV genes in extraembryonic mesoderm development, identification of endogenous retrovirus env genes in the genome of Gallus gallus and it profile during the early embryogenesis. The role of endogenous retrovirus ENV genes in the placental mesenchymal cells

Former Lab Members

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Pavlo Areshkov, PhD

Pavlo obtained PhD degree in Molecular Biology at the department of biosynthesis of nucleic (currently the Laboratory of biosynthesis of nucleic acids) at the Institute of Molecular Biology and Genetics NAS of Ukraine in 2015. His research interests lay in the field of tumor initiation and development and therapeutic application of stem cell technology. One of main focuses regards the human placenta-derived multipotent cells (PDMC) as a potential instrument of cancer treatment and the result was that rats with dimethylhydrazine-induced colon tumors after PDMC transplantation possess decreased survival rate in a late stages of cancer progression. Another project deals with molecular targets associated with fetal growth and development, namely, expression ERVW-1/Syncytin-1 in placental mesenchymal cells

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Hanna Svitina, PhD

I obtained my PhD Biological Sciences degree in 2017, at the Educational and Scientific Centre “Institute of Biology and Medicine”, the Taras Shevchenko University of Kyiv, Kyiv, Ukraine. My scientific research experience is focused on processing and characterization of stem cells ex vivo, namely primary mesenchymal stem cell culture obtained from human/rat placenta, rat bone marrow, human adipose tissue and primary human chondrocytes from an intervertebral hernia. Also, I was involved in other groups that were developing a new stem therapy product and organizing pre-clinical and clinical assessment of effectiveness of the cell therapy in curing several diseases (regeneration of cartilaginous tissue, autoimmune diseases, colon cancer). I worked at Institute of Cell Therapy since 2010 until 2018. My research was dedicated to the establishment of origin of human and rat placenta-derived multipotent cells (PDMC). Basic characteristics of PDMC included mesenchymal and trophoblast features

Team

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Volodymyr%20Shablii-solo-page

Volodymyr Shablii, PhD

Head of PlacentaStemCell Laboratory

I obtained PhD in Biotechnology at the department of Human Genetics, Institute of Molecular Biology and Genetics NAS of Ukraine in 2014. My research was focused on the study of mesenchymal stem cells isolated from placenta at different stages of human development (first-trimester and full term placenta), special attention was paid to the study of immunophenotype of cells, gene expression and multipotency of high proliferative subpopulation of placenta-derived multipotent cells (PDMCs). Furthermore, my research interests include the development of protocols for cryopreservation of placenta tissue as a source of various populations of stem cells. As a group leader I supervise different research projects that were performed in PlacentaStemCell Lab (PSC Lab). As a deputy director of Cryobank I am involved in the development of clinical-grade protocols of processing (isolation, expansion, and cryopreservation) of different cell based products. Nowadays, I launch the project dedicated to study the role of expression of endogenous retrovirus env ERVW-1/Syncytin-1 gene in extraembryonic mesoderm cells. For in vivo functional study of ENVs we are working on the establishing chicken embryo model.

Feedback

Please write on this email address for further collaboration

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