Transplantation of placenta-derived multipotent cells in rats with dimethylhydrazine-induced colon cancer decreases the survival rate
Svitina H, Skrypkina I, Areshkov P, Kyryk V, Bukreieva T, Klymenko P, Garmanchuk L, Lobintseva G, Shablii V.
Oncol Lett. 2018 Apr;15(4):5034-5042. doi: 10.3892/ol.2018.7996. Epub 2018 Feb 8.
In our study, PDMCs transplanted at middle phase of CC did not affect either the number or the area of the forming tumours, but detailed analysis of the area of tumours depending on the invasion depth revealed an unexpected result due to the selectivity of stimulation of the most invasiveness tumours (stage T4 tumours).
Intravenous allogeneic transplantation of PDMCs reduced the survival rate of rats with colon cancer by 17 days.
PDMCs (labeled with GFP) from rats engrafted into tissues of the normal intestine, tumours, lungs, liver, and spleen of rats for five weeks after intravenous transplantation. Immunohistochemistry fluorescence of rat tumour colon tissues: Anti-GFP are green, nuclei are blue. Scale bar, 10 µm; magnification, ×630
